Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

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Transcription profiling of human age-dichotomized ER+ breast tumors


ABSTRACT: To investigate the biological basis between aging and sporadic breast cancer incidence and prognosis, RNA samples from matched ER+ invasive breast cancers diagnosed in either young (â?¤45) or old (â?¥70) women were analyzed by expression microarrays Experiment Overall Design: ER+ breast cancers collected from either young or old women, well matched for other clinical parameters were analyzed using expression microarrays. Age associated tumor subtypes and enrichment of pre-defined gene signatures were identified. Age associated differential expression and an age signature (gene-based classifier) was assessed

ORGANISM(S): Homo sapiens

SUBMITTER: Christina Yau 

PROVIDER: E-GEOD-8193 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications


<h4>Introduction</h4>Age is one of the most important risk factors for human malignancies, including breast cancer; in addition, age at diagnosis has been shown to be an independent indicator of breast cancer prognosis. Except for inherited forms of breast cancer, however, there is little genetic or epigenetic understanding of the biological basis linking aging with sporadic breast cancer incidence and its clinical behavior.<h4>Methods</h4>DNA and RNA samples from matched estrogen receptor (ER)-  ...[more]

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