Ontology highlight
ABSTRACT:
ORGANISM(S): Streptococcus sp. 'group A'
SUBMITTER: Samuel Shelburne
PROVIDER: E-GEOD-10156 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Shelburne Samuel A SA Keith David D Horstmann Nicola N Sumby Paul P Davenport Michael T MT Graviss Edward A EA Brennan Richard G RG Musser James M JM
Proceedings of the National Academy of Sciences of the United States of America 20080129 5
Although central to pathogenesis, the molecular mechanisms used by microbes to regulate virulence factor production in specific environments during host-pathogen interaction are poorly defined. Several recent ex vivo and in vivo studies have found that the level of group A Streptococcus (GAS) virulence factor gene transcripts is temporally related to altered expression of genes encoding carbohydrate utilization proteins. These findings stimulated us to analyze the role in pathogenesis of catabol ...[more]