Unknown,Transcriptomics,Genomics,Proteomics

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Analysis of the group A Streptococcus CcpA Transcriptome


ABSTRACT: This study evaluate how catabolite control protein A (CcpA) inactivation affected gene transcript levels in the group A Streptococcus serotype M1 strain MGAS5005 during growth in standard laboratory medium. Keywords: transcriptome analysis 4 replicates of strain MGAS5005 and delta_cppA were grown in THY to early and late logarithmic growth phases. The transcriptomes of each samples were then analyzed.

ORGANISM(S): Streptococcus sp. 'group A'

SUBMITTER: Samuel Shelburne 

PROVIDER: E-GEOD-10156 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

A direct link between carbohydrate utilization and virulence in the major human pathogen group A Streptococcus.

Shelburne Samuel A SA   Keith David D   Horstmann Nicola N   Sumby Paul P   Davenport Michael T MT   Graviss Edward A EA   Brennan Richard G RG   Musser James M JM  

Proceedings of the National Academy of Sciences of the United States of America 20080129 5


Although central to pathogenesis, the molecular mechanisms used by microbes to regulate virulence factor production in specific environments during host-pathogen interaction are poorly defined. Several recent ex vivo and in vivo studies have found that the level of group A Streptococcus (GAS) virulence factor gene transcripts is temporally related to altered expression of genes encoding carbohydrate utilization proteins. These findings stimulated us to analyze the role in pathogenesis of catabol  ...[more]

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