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Transcription profiling of mouse naive and tolerant macrophages treated with MDP- and Pam3CSK4

ABSTRACT: Most of the genes were self-tolerized by Pam3CSK4 and MDP but there was no or minimal cross-tolerization. The transcriptome induced via Nod2 stimulation is greatly expanded in TLR2-tolerant macrophages. Experiment Overall Design: Genes induced by Pam3CSK4 or MDP were selected based on a three-fold increase over expression levels in unstimulated macrophages. Tolerized genes are defined as genes downregulated more than 2-fold in tolerant macrophages stimulated with Pam3CSK4 or MDP.

ORGANISM(S): Mus musculus

SUBMITTER: Yun-Gi Kim

PROVIDER: E-GEOD-10182 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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