Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

0

Transcription profiling of mouse laser-microdissected motorneurons in a Spinal Muscular Atrophy model (SMA)


ABSTRACT: Spinal Muscular Atrophy (SMA) is an autosomal recessive motor neuron disease and is the second most common genetic disorder leading to death in childhood. Stem cell transplantation could represent a therapeutic approach for motor neuron diseases such as SMA. We examined the theraputics effects of a spinal cord neural stem cell population and their ability to modify SMA phenotype. Microarray technology was used to assess the global gene expression profile of laser-microdissected motoneurons obtained by transplanted and veichle treated SMA, and wildtype mice. Experiment Overall Design: The microarray data derived from three different groups: wildtype controls (vehicle treated), transgenic SMA (vehicle treated) and transplanted SMA mice. Each population consists of three RNA profiling samples.

ORGANISM(S): Mus musculus

SUBMITTER: Stefania Corti 

PROVIDER: E-GEOD-10224 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

Similar Datasets

2013-12-01 | E-GEOD-19674 | biostudies-arrayexpress
2009-10-31 | E-GEOD-16710 | biostudies-arrayexpress
2010-05-27 | E-GEOD-19701 | biostudies-arrayexpress
2013-01-04 | E-GEOD-27205 | biostudies-arrayexpress
2008-06-11 | E-GEOD-10953 | biostudies-arrayexpress
2007-09-07 | E-GEOD-3075 | biostudies-arrayexpress
2008-08-06 | GSE10224 | GEO
2015-09-01 | E-GEOD-69175 | biostudies-arrayexpress
2012-12-04 | E-GEOD-38820 | biostudies-arrayexpress
2013-10-01 | E-GEOD-46298 | biostudies-arrayexpress