Transcription profiling of mouse laser-microdissected motorneurons in a Spinal Muscular Atrophy model (SMA)
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ABSTRACT: Spinal Muscular Atrophy (SMA) is an autosomal recessive motor neuron disease and is the second most common genetic disorder leading to death in childhood. Stem cell transplantation could represent a therapeutic approach for motor neuron diseases such as SMA. We examined the theraputics effects of a spinal cord neural stem cell population and their ability to modify SMA phenotype. Microarray technology was used to assess the global gene expression profile of laser-microdissected motoneurons obtained by transplanted and veichle treated SMA, and wildtype mice. Experiment Overall Design: The microarray data derived from three different groups: wildtype controls (vehicle treated), transgenic SMA (vehicle treated) and transplanted SMA mice. Each population consists of three RNA profiling samples.
ORGANISM(S): Mus musculus
SUBMITTER: Stefania Corti
PROVIDER: E-GEOD-10224 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
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