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Gene Expression Analysis of laser-microdissected motorneurons in Spinal Muscular Atrophy (SMA)

ABSTRACT: Spinal Muscular Atrophy (SMA) is an autosomal recessive motor neuron disease and is the second most common genetic disorder leading to death in childhood. Stem cell transplantation could represent a therapeutic approach for motor neuron diseases such as SMA. We examined the theraputics effects of a spinal cord neural stem cell population and their ability to modify SMA phenotype. Microarray technology was used to assess the global gene expression profile of laser-microdissected motoneurons obtained by transplanted and veichle treated SMA, and wildtype mice. Keywords: Comparative Gene Expression Analysis

ORGANISM(S): Mus musculus

PROVIDER: GSE10224 | GEO | 2008/08/06

SECONDARY ACCESSION(S): PRJNA108289

REPOSITORIES: GEO

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Transcription profiling of mouse laser-microdissected motorneurons in a Spinal Muscular Atrophy model (SMA)

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