Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Transcription profiling of phenylepherine response in rat neonatal ventricular myocytes


ABSTRACT: Title: Regulation of gene expression through mitogen-activated protein kinase cascades in cardiac myocytes.
Description: We aim to identify the changes in gene expression induced in rat
neonatal ventricular myocytes, a well established cell culture model,
by phenylepherine, a known hypertrophic agonist, and to determine which
of the changes are mediated through the ERK cascade. In addition, we
intend to extend the previous studies (EXP_TKAC_0102_01 and
EXP_TKAC_1103_02) on endothelin-1 induced hypertrophy and the oxidative
stress induced by H2O2 by using additional concentrations and timepoints.

ORGANISM(S): Rattus norvegicus

SUBMITTER: unknown unknown 

PROVIDER: E-MIMR-37 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

p90 ribosomal S6 kinases play a significant role in early gene regulation in the cardiomyocyte response to G(q)-protein-coupled receptor stimuli, endothelin-1 and α(1)-adrenergic receptor agonists.

Amirak Emre E   Fuller Stephen J SJ   Sugden Peter H PH   Clerk Angela A  

The Biochemical journal 20130301 2


ERK1/2 (extracellular-signal-regulated kinase 1/2) and their substrates RSKs (p90 ribosomal S6 kinases) phosphorylate different transcription factors, contributing differentially to transcriptomic profiles. In cardiomyocytes ERK1/2 are required for >70% of the transcriptomic response to endothelin-1. In the present study we investigated the role of RSKs in the transcriptomic responses to the G(q)-protein-coupled receptor agonists endothelin-1, phenylephrine (a generic α(1)-adrenergic receptor ag  ...[more]

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