Ontology highlight
ABSTRACT:
ORGANISM(S): Schizosaccharomyces pombe
SUBMITTER: Shiv Grewal
PROVIDER: E-GEOD-10561 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Zhang Ke K Mosch Kerstin K Fischle Wolfgang W Grewal Shiv I S SI
Nature structural & molecular biology 20080316 4
Heterochromatin assembly, involving methylation of histone H3 lysine 9 (H3K9me), regulates various chromosomal processes. In fission yeast, heterochromatin targeted to specific repeat loci in an RNAi-dependent manner spreads across extended domains to exert regional epigenetic control. The Clr4 methyltransferase complex (ClrC) is responsible for nucleation and spreading of heterochromatin; however, its recruitment to heterochromatic repeats is poorly understood. Here we demonstrate that ClrC com ...[more]