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Expression data from human colonic biopsy sample

ABSTRACT: Gene expression profile based classification of colonic diseases are suitable for identification of diagnostic mRNA expression patterns which can establish the basis of a new molecular biological diagnostic method Keywords: whole genomic expression Total RNA was extracted from colonic biosy samples CRC and hybridized on Affymetrix HGU133 Plus 2.0 microarrays

ORGANISM(S): Homo sapiens

SUBMITTER: Norbert Solymosi

PROVIDER: E-GEOD-10714 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Reversal of gene expression changes in the colorectal normal-adenoma pathway by NS398 selective COX2 inhibitor.

Galamb O O Spisák S S Sipos F F Tóth K K Solymosi N N Wichmann B B Krenács T T Valcz G G Tulassay Z Z Molnár B B

British journal of cancer 20100119 4

<h4>Background and aims</h4>Treatment of colorectal adenomas with selective cyclooxygenase-2 inhibitors can contribute to the chemoprevention of colorectal cancer (CRC), but the molecular background of their effect is not fully understood. We analysed the gene expression modulatory effect of N-(2-cyclohexyloxy-4-nitrophenyl)-methanesulfonamide (NS398) on HT29 cells to be correlated with expression data gained from biopsy samples.<h4>Methods</h4>HT29 colon adenocarcinoma cells were treated with N ...[more]

PMID: 20087348

Publication: 1/2

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