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Expression data from normal and CRC human peripheral blood samples

ABSTRACT: The whole-genome oligonucleotide microarray analysis of peripheral blood samples can contribute to the determination of distant blood markers of local pathophysiological alterations in colorectal diseases. These markers can lead to alternative screening procedures. Keywords: whole genomic expression Total RNA was extracted from peripheral blood samples of healthy patients and patients with CRC and hybridized on Affymetrix HGU133 Plus 2.0 microarrays

ORGANISM(S): Homo sapiens

SUBMITTER: Norbert Solymosi

PROVIDER: E-GEOD-10715 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Diagnostic mRNA expression patterns of inflamed, benign, and malignant colorectal biopsy specimen and their correlation with peripheral blood results.

Galamb Orsolya O Sipos Ferenc F Solymosi Norbert N Spisák Sándor S Krenács Tibor T Tóth Kinga K Tulassay Zsolt Z Molnár Béla B

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 20081001 10

<h4>Purpose</h4>Gene expression profile (GEP)-based classification of colonic diseases is a new method for diagnostic purposes. Our aim was to develop diagnostic mRNA expression patterns that may establish the basis of a new molecular biological diagnostic method.<h4>Experimental design</h4>Total RNA was extracted, amplified, and biotinylated from frozen colonic biopsies of patients with colorectal cancer (n=22), adenoma (n=20), hyperplastic polyp (n=11), inflammatory bowel disease (n=21), and h ...[more]

PMID: 18843029

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