Transcription profiling of human histologically normal breast tissues reveals proliferative genes dominate malignancy-risk gene signature
Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Dung-Tsa Chen
PROVIDER: E-GEOD-10780 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Proliferative genes dominate malignancy-risk gene signature in histologically-normal breast tissue.
Chen Dung-Tsa DT Nasir Aejaz A Culhane Aedin A Venkataramu Chinnambally C Fulp William W Rubio Renee R Wang Tao T Agrawal Deepak D McCarthy Susan M SM Gruidl Mike M Bloom Gregory G Anderson Tove T White Joe J Quackenbush John J Yeatman Timothy T
Breast cancer research and treatment 20090306 2
Historical data have indicated the potential for the histologically-normal breast to harbor pre-malignant changes at the molecular level. We postulated that a histologically-normal tissue with "tumor-like" gene expression pattern might harbor substantial risk for future cancer development. Genes associated with these high-risk tissues were considered to be "malignancy-risk genes". From a total of 90 breast cancer patients, we collected a set of 143 histologically-normal breast tissues derived fr ...[more]
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