Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Andrew Leask
PROVIDER: E-GEOD-1081 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Xu Shi-wen SW Howat Sarah L SL Renzoni Elisabetta A EA Holmes Alan A Pearson Jeremy D JD Dashwood Michael R MR Bou-Gharios George G Denton Christopher P CP du Bois Roland M RM Black Carol M CM Leask Andrew A Abraham David J DJ
The Journal of biological chemistry 20040323 22
The endothelins are a family of endothelium-derived peptides that possess a variety of biological activities, including potent vasoconstriction. Endothelin-1 (ET-1) is up-regulated during tissue repair and pulmonary fibrosis. Here, we use genome-wide expression array analysis to show that the addition of ET-1 (100 nm, 4 h) to normal lung fibroblasts directly induces expression of matrix and matrix-associated genes, including the profibrotic protein CCN2 (connective tissue growth factor, or CTGF) ...[more]