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Expression patterns of cDNAs in gamma-irradiation induced T-cell lymphomas

ABSTRACT: This set of data contains the expression levels of cDNAs in T-cell lymphoblastci lymphomas induced by gamma-irradiation. These tumor samples were compared to normal thymuses Keywords: Tumor profiles, comparison of tumoral versus wilf-type tissues, lymphomas and leukemias C57BL/6J animals were maintained in our animal facilities following the appropriate ethical recommendations from our institutions. For tumor induction, 4-week-old mice of both sexes were exposed to four weekly doses of 1.75 Gy/dose of ionizing gamma radiation. Treated mice were observed daily until moribund, then sacrificed and autopsied. DNA, RNA and proteins were isolated from these samples using routine procedures.

ORGANISM(S): Mus musculus

SUBMITTER: Ignacio PÃ©rez de Castro

PROVIDER: E-GEOD-10859 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Genetic and epigenetic silencing of microRNA-203 enhances ABL1 and BCR-ABL1 oncogene expression.

Bueno María J MJ Pérez de Castro Ignacio I Gómez de Cedrón Marta M Santos Javier J Calin George A GA Cigudosa Juan C JC Croce Carlo M CM Fernández-Piqueras José J Malumbres Marcos M

Cancer cell 20080601 6

The mammalian genome contains several hundred microRNAs that regulate gene expression through modulation of target mRNAs. Here, we report a fragile chromosomal region lost in specific hematopoietic malignancies. This 7 Mb region encodes about 12% of all genomic microRNAs, including miR-203. This microRNA is additionally hypermethylated in several hematopoietic tumors, including chronic myelogenous leukemias and some acute lymphoblastic leukemias. A putative miR-203 target, ABL1, is specifically ...[more]

PMID: 18538733

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| phs001645 | dbGaP

The codon 72 polymorphism of p53 regulates interactions with NF-κB and transactivation of genes involoved in immunity and inflamation

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