Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Ignacio Pérez de Castro
PROVIDER: E-GEOD-10858 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Cancer cell 20080601 6
The mammalian genome contains several hundred microRNAs that regulate gene expression through modulation of target mRNAs. Here, we report a fragile chromosomal region lost in specific hematopoietic malignancies. This 7 Mb region encodes about 12% of all genomic microRNAs, including miR-203. This microRNA is additionally hypermethylated in several hematopoietic tumors, including chronic myelogenous leukemias and some acute lymphoblastic leukemias. A putative miR-203 target, ABL1, is specifically ...[more]