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Comparative Genomic hybridization of gamma-irradiated T-cell lymphomas

ABSTRACT: This analysis compares the signal of DNA from T-cell lymphoblastic lymphomas induced by gamma-irradiation versus normal thymuses Keywords: Tumor profiles, comparison of tumoral versus wilf-type tissues, lymphomas and leukemias C57BL/6J animals were maintained in our animal facilities following the appropriate ethical recommendations from our institutions. For tumor induction, 4-week-old mice of both sexes were exposed to four weekly doses of 1.75 Gy/dose of ionizing gamma radiation. Treated mice were observed daily until moribund, then sacrificed and autopsied. DNA, RNA and proteins were isolated from these samples using routine procedures.

ORGANISM(S): Mus musculus

SUBMITTER: Ignacio Pérez de Castro 

PROVIDER: E-GEOD-10858 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Genetic and epigenetic silencing of microRNA-203 enhances ABL1 and BCR-ABL1 oncogene expression.

Bueno María J MJ   Pérez de Castro Ignacio I   Gómez de Cedrón Marta M   Santos Javier J   Calin George A GA   Cigudosa Juan C JC   Croce Carlo M CM   Fernández-Piqueras José J   Malumbres Marcos M  

Cancer cell 20080601 6

The mammalian genome contains several hundred microRNAs that regulate gene expression through modulation of target mRNAs. Here, we report a fragile chromosomal region lost in specific hematopoietic malignancies. This 7 Mb region encodes about 12% of all genomic microRNAs, including miR-203. This microRNA is additionally hypermethylated in several hematopoietic tumors, including chronic myelogenous leukemias and some acute lymphoblastic leukemias. A putative miR-203 target, ABL1, is specifically  ...[more]

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