Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

0

Gamma-irradiation induced T-cell lymphomas (miRNA study)

ABSTRACT: This set of data contains the expression levels of cDNAs in T-cell lymphoblastic lymphomas induced by gamma-irradiation. These tumor samples were compared to normal thymuses Keywords: Tumor profiles, comparison of tumoral versus wild-type tissues, lymphomas and leukemias C57BL/6J animals were maintained in our animal facilities following the appropriate ethical recommendations from our institutions. For tumor induction, 4-week-old mice of both sexes were exposed to four weekly doses of 1.75 Gy/dose of ionizing gamma radiation. Treated mice were observed daily until moribund, then sacrificed and autopsied. DNA, RNA and proteins were isolated from these samples using routine procedures.

ORGANISM(S): Mus musculus

SUBMITTER: Ignacio Pérez de Castro 

PROVIDER: E-GEOD-10891 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

Json Xml
altmetric image

Publications

Genetic and epigenetic silencing of microRNA-203 enhances ABL1 and BCR-ABL1 oncogene expression.

Bueno María J MJ   Pérez de Castro Ignacio I   Gómez de Cedrón Marta M   Santos Javier J   Calin George A GA   Cigudosa Juan C JC   Croce Carlo M CM   Fernández-Piqueras José J   Malumbres Marcos M  

Cancer cell 20080601 6

The mammalian genome contains several hundred microRNAs that regulate gene expression through modulation of target mRNAs. Here, we report a fragile chromosomal region lost in specific hematopoietic malignancies. This 7 Mb region encodes about 12% of all genomic microRNAs, including miR-203. This microRNA is additionally hypermethylated in several hematopoietic tumors, including chronic myelogenous leukemias and some acute lymphoblastic leukemias. A putative miR-203 target, ABL1, is specifically  ...[more]

Similar Datasets

Transcriptomics Comparative Genomic hybridization of gamma-irradiated T-cell lymphomas
2010-05-26 | E-GEOD-10858 | biostudies-arrayexpress
Transcriptomics Expression patterns of cDNAs in gamma-irradiation induced T-cell lymphomas
2010-05-26 | E-GEOD-10859 | biostudies-arrayexpress
Transcriptomics T-cell lymphoblastic lymphomas induced by gamma-irradiation
2010-05-26 | E-GEOD-10861 | biostudies-arrayexpress
Genomics Comparative Genomic hybridization of gamma-irradiated T-cell lymphomas
2008-06-26 | GSE10858 | GEO
Transcriptomics Expression patterns of cDNAs in gamma-irradiation induced T-cell lymphomas
2008-06-26 | GSE10859 | GEO
Genomics Gamma-irradiation induced T-cell lymphomas (miRNA study)
2008-06-26 | GSE10891 | GEO
Transcriptomics Transcription profiling of mouseB-cell lymphomas with defined genetic alterations in p53 or p73
2008-12-05 | E-MEXP-1620 | biostudies-arrayexpress
Transcriptomics The codon 72 polymorphism of p53 regulates interactions with NF-κB and transactivation of genes involoved in immunity and inflamation
2011-01-25 | E-GEOD-26851 | biostudies-arrayexpress
Transcriptomics Mouse placenta irradiaion
2013-08-16 | E-GEOD-49923 | biostudies-arrayexpress
Genomic Genomic Landscape of Cutaneous Diffuse Large B Cell Lymphoma
| phs001645 | dbGaP