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RNAi profiling of mouse hippocampal neurons infected with lentivirus expressing Npas4-RNAi or control-RNAi to study Npas4-regulated genes

ABSTRACT: We performed a DNA microarray experiment to identify activity-regulated genes that are misregulated in the absence of Npas4. Experiment Overall Design: We infected mouse hippocampal neurons with lentivirus expressing Npas4-RNAi or control-RNAi @ 3 DIV and depolarized the neurons @ 8 DIV with 50 mM of KCl for 0, 1, 3 or 6 hours. Neurons were lysed, mRNA isolated and hybridized to Affymetrix arrays. Data were collected from 3 independent experiments.

ORGANISM(S): Mus musculus

SUBMITTER: Yingxi Lin 

PROVIDER: E-GEOD-11258 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Activity-dependent regulation of inhibitory synapse development by Npas4.

Lin Yingxi Y   Bloodgood Brenda L BL   Hauser Jessica L JL   Lapan Ariya D AD   Koon Alex C AC   Kim Tae-Kyung TK   Hu Linda S LS   Malik Athar N AN   Greenberg Michael E ME  

Nature 20080924 7217

Neuronal activity regulates the development and maturation of excitatory and inhibitory synapses in the mammalian brain. Several recent studies have identified signalling networks within neurons that control excitatory synapse development. However, less is known about the molecular mechanisms that regulate the activity-dependent development of GABA (gamma-aminobutyric acid)-releasing inhibitory synapses. Here we report the identification of a transcription factor, Npas4, that plays a role in the  ...[more]

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