Roles for microRNAs, miR-93 and miR-130b, and TP53INP1 tumor suppressor in cell growth dysregulation by HTLV-1
Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Man Lung Yeung
PROVIDER: E-GEOD-11577 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Roles for microRNAs, miR-93 and miR-130b, and tumor protein 53-induced nuclear protein 1 tumor suppressor in cell growth dysregulation by human T-cell lymphotrophic virus 1.
Yeung Man Lung ML Yasunaga Jun-ichirou J Bennasser Yamina Y Dusetti Nelson N Harris David D Ahmad Nafees N Matsuoka Masao M Jeang Kuan-Teh KT
Cancer research 20081101 21
A role for microRNAs (miRNA) in human T-cell leukemia virus 1 (HTLV-1)-mediated cellular transformation has not been described. Here, we profiled miRNA expression in HTLV-1-transformed human T-cell lines and primary peripheral blood mononuclear cells from adult T-cell leukemia patients. Analyses of 11 different profiles revealed six miRNAs that were consistently up-regulated. Two of the up-regulated miRNAs (miR-93 and miR-130b) target the 3' untranslated region (3'UTR) of the mRNA for a tumor su ...[more]
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