Naive/activated ANOVA group
Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Anjana Rao
PROVIDER: E-GEOD-11832 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Regulation of CD45 alternative splicing by heterogeneous ribonucleoprotein, hnRNPLL.
Oberdoerffer Shalini S Moita Luis Ferreira LF Neems Daniel D Freitas Rui P RP Hacohen Nir N Rao Anjana A
Science (New York, N.Y.) 20080710 5889
The transition from naïve to activated T cells is marked by alternative splicing of pre-mRNA encoding the transmembrane phosphatase CD45. Using a short hairpin RNA interference screen, we identified heterogeneous ribonucleoprotein L-like (hnRNPLL) as a critical inducible regulator of CD45 alternative splicing. HnRNPLL was up-regulated in stimulated T cells, bound CD45 transcripts, and was both necessary and sufficient for CD45 alternative splicing. Depletion or overexpression of hnRNPLL in B and ...[more]
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