Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

0

Gene expression data in heifers with persistently infected (PI) or transiently infected (TI) fetuses.


ABSTRACT: The response to the presence of the ncpBVDV-infected PI or TI fetus is expected to provide information on the impact of the PI fetus on the immune response of the dam Fetal PI infection was induced by intranasal inoculation of pregnant heifers with ncpBVDV on day 75 of gestation. Fetal transient infection (TI) was induced by infection of pregnant heifers with ncpBVDV on day 175 of gestation. Control heifers were kept uninfected. Blood samples from pregnant heifers of the PI and control groups were collected on day 160 of gestation. Blood samples of PI, TI and healthy fetus carrying heifers were collected for microarray on day 190 of gestation.

ORGANISM(S): Bos taurus

SUBMITTER: Kate McInnerney 

PROVIDER: E-GEOD-11835 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

altmetric image

Publications

Persistent fetal infection with bovine viral diarrhea virus differentially affects maternal blood cell signal transduction pathways.

Smirnova Natalia P NP   Ptitsyn Andrey A AA   Austin Kathleen J KJ   Bielefeldt-Ohmann Helle H   Van Campen Hana H   Han Hyungchul H   van Olphen Alberto L AL   Hansen Thomas R TR  

Physiological genomics 20081118 3


The consequences of viral infection during pregnancy include impact on fetal and maternal immune responses and on fetal development. Transplacental infection in cattle with noncytopathic bovine viral diarrhea virus (ncpBVDV) during early gestation results in persistently infected (PI) fetuses with life-long viremia and susceptibility to infections. Infection of the fetus during the third trimester or after birth leads to a transient infection cleared by a competent immune system. We hypothesized  ...[more]

Similar Datasets

2024-05-29 | GSE255721 | GEO
2009-07-01 | E-GEOD-11853 | biostudies-arrayexpress
2009-06-15 | GSE11835 | GEO
2016-05-17 | E-GEOD-71205 | biostudies-arrayexpress
2024-10-17 | PXD052863 | Pride
2016-05-17 | E-GEOD-75304 | biostudies-arrayexpress
2016-05-15 | GSE81449 | GEO
2007-11-06 | E-GEOD-3215 | biostudies-arrayexpress
2020-08-25 | GSE148323 | GEO
2016-05-15 | E-GEOD-81449 | biostudies-arrayexpress