Transcription profiling of rat fetal kidney samples from offspring of hyperinsulinemic mothers
Ontology highlight
ABSTRACT:
ORGANISM(S): Rattus norvegicus
SUBMITTER: Yoav Smith
PROVIDER: E-GEOD-3215 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Adult hypertension in intrauterine growth-restricted offspring of hyperinsulinemic rats: evidence of subtle renal damage.
Bursztyn Michael M Gross Marie-Luise ML Goltser-Dubner Tania T Koleganova Nadja N Birman Tatiana T Smith Yoav Y Ariel Ilana I
Hypertension (Dallas, Tex. : 1979) 20060821 4
In humans, intrauterine growth-restricted newborns are prone to develop hypertension as adults. We studied a rat model of pregnancy-induced hypertension associated with intrauterine growth restriction (IUGR) produced by chronic administration of insulin. Fetuses of hyperinsulinemic dams (HDs) were smaller than those of normal dams (5.1+/-0.4 g versus 5.6+/-0.1 g, respectively; P<0.05). At 16 weeks of age, tail-cuff systolic blood pressure was measured, the rats were placed in metabolic cages and ...[more]
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