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Role of inherent strain differences in prenatally induced differential metabolic syndrome phenotype and gene expression

ABSTRACT: There is much evidence suggesting that gene-environment interactions underlying the developmental origins of the metabolic syndrome. Previously, we have induced a metabolic syndrome phenotype in mice though prenatal undernutrition; however, the C57BL/6J strain exhibited significantly more metrics of the metabolic syndrome than the A/J strain. We used microarrays to detail the global programme of gene expression underlying the strain differences in the prenatal induction of the adult development of the metabolic syndrome. We focused on liver function and gene expression because of it's centrol role in many aspects of the metabolic syndrome including glucose and lipid control. Keywords: disease state analysis between mouse strains Pregnant A/J and C57BL/6J mice were either exposed to prenatal undernutrition during pregnancy or control conditions. The livers from 32 male offspring (8 per group within each of the two strains) were dissected out at 7 months of age and total RNA was extracted and hybridization on Affymetrix microarrays.

ORGANISM(S): Mus musculus

SUBMITTER: brian knight

PROVIDER: E-GEOD-12117 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Role of inherent strain differences in prenatally induced differential metabolic syndrome phenotype and gene expression

Project description:There is much evidence suggesting that gene-environment interactions underlying the developmental origins of the metabolic syndrome. Previously, we have induced a metabolic syndrome phenotype in mice though prenatal undernutrition; however, the C57BL/6J strain exhibited significantly more metrics of the metabolic syndrome than the A/J strain. We used microarrays to detail the global programme of gene expression underlying the strain differences in the prenatal induction of the adult development of the metabolic syndrome. We focused on liver function and gene expression because of it's centrol role in many aspects of the metabolic syndrome including glucose and lipid control. Keywords: disease state analysis between mouse strains

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brain expression data from adult mice prenatally exposed to ethanol

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brain expression data from adult mice prenatally exposed to ethanol

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Brain expression data from fetal mouse brains prenatally exposed to ethanol

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2013-01-08 | E-GEOD-43324 | biostudies-arrayexpress

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