Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Almudena Ramiro
PROVIDER: E-GEOD-12176 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
de Yébenes Virginia G VG Belver Laura L Pisano David G DG González Susana S Villasante Aranzazu A Croce Carlo C He Lin L Ramiro Almudena R AR
The Journal of experimental medicine 20080901 10
Activated B cells reshape their primary antibody repertoire after antigen encounter by two molecular mechanisms: somatic hypermutation (SHM) and class switch recombination (CSR). SHM and CSR are initiated by activation-induced cytidine deaminase (AID) through the deamination of cytosine residues on the immunoglobulin loci, which leads to the generation of DNA mutations or double-strand break intermediates. As a bystander effect, endogenous AID levels can also promote the generation of chromosome ...[more]