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MicroRNA expression profile of activated versus non activated primary B cells


ABSTRACT: microRNA expression profile in 5 indepent sets of paired samples of LPS+IL-4 activated versus non activated primary mouse spleen B cells Keywords: cell type comparison Activated B cells for miRNA array analysis were obtained after CFSE labelling (Molecular Probes), LPS+IL4 stimulation for 3 days and sorting of cells that had undergone at least 1 cell division. Sortings were performed with a FACSAria cell sorter (BD Biosciences).

ORGANISM(S): Mus musculus

SUBMITTER: Almudena Ramiro 

PROVIDER: E-GEOD-12176 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

miR-181b negatively regulates activation-induced cytidine deaminase in B cells.

de Yébenes Virginia G VG   Belver Laura L   Pisano David G DG   González Susana S   Villasante Aranzazu A   Croce Carlo C   He Lin L   Ramiro Almudena R AR  

The Journal of experimental medicine 20080901 10


Activated B cells reshape their primary antibody repertoire after antigen encounter by two molecular mechanisms: somatic hypermutation (SHM) and class switch recombination (CSR). SHM and CSR are initiated by activation-induced cytidine deaminase (AID) through the deamination of cytosine residues on the immunoglobulin loci, which leads to the generation of DNA mutations or double-strand break intermediates. As a bystander effect, endogenous AID levels can also promote the generation of chromosome  ...[more]

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