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MicroRNA expression profile of activated primary B cells and miR181b overexpressing primary B cells

ABSTRACT: This SuperSeries is composed of the following subset Series: GSE12156: Murine spleen B cells miR181b vs control (G4122A) GSE12158: Murine spleen B cells miR181b vs control (G4122F) GSE12176: microRNA expression profile of activated versus non activated primary B cells Refer to individual Series

ORGANISM(S): Mus musculus

SUBMITTER: Almudena Ramiro

PROVIDER: E-GEOD-12186 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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miR-181b negatively regulates activation-induced cytidine deaminase in B cells.

de Yébenes Virginia G VG Belver Laura L Pisano David G DG González Susana S Villasante Aranzazu A Croce Carlo C He Lin L Ramiro Almudena R AR

The Journal of experimental medicine 20080901 10

Activated B cells reshape their primary antibody repertoire after antigen encounter by two molecular mechanisms: somatic hypermutation (SHM) and class switch recombination (CSR). SHM and CSR are initiated by activation-induced cytidine deaminase (AID) through the deamination of cytosine residues on the immunoglobulin loci, which leads to the generation of DNA mutations or double-strand break intermediates. As a bystander effect, endogenous AID levels can also promote the generation of chromosome ...[more]

PMID: 18762567

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