Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

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Drosophila melanosgaster 2nd chromosome substitution lines


ABSTRACT: Transcriptional profiling of Drosophila melanogaster 2nd chromosome substitution lines; Background chromosomes are identical across lines; 2nd chromosomes are different across line and can be homozygous or heterozygous within each line Keywords: Natural variation Loop design with 8 genotypes

ORGANISM(S): Drosophila melanogaster

SUBMITTER: Bernardo Lemos 

PROVIDER: E-GEOD-12191 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Dominance and the evolutionary accumulation of cis- and trans-effects on gene expression.

Lemos Bernardo B   Araripe Luciana O LO   Fontanillas Pierre P   Hartl Daniel L DL  

Proceedings of the National Academy of Sciences of the United States of America 20080912 38


Gene expression levels appear to be under pervasive stabilizing selection. Yet the genetic architecture underlying abundant gene expression diversity within and between populations remains elusive. Here, we investigated the role of dominance in the segregation of cis- and trans-regulation within and between populations. We used chromosome substitution lines of Drosophila melanogaster to show that (i) >70% of the genes that are differentially expressed between two homozygous lines are masked in t  ...[more]

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