Aspergillus CEA10 compared to SRBA mutant under hypoxic conditions
Ontology highlight
ABSTRACT:
ORGANISM(S): Aspergillus fumigatus
SUBMITTER: Robert Cramer
PROVIDER: E-GEOD-12376 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
A sterol-regulatory element binding protein is required for cell polarity, hypoxia adaptation, azole drug resistance, and virulence in Aspergillus fumigatus.
Willger Sven D SD Puttikamonkul Srisombat S Kim Kwang-Hyung KH Burritt James B JB Grahl Nora N Metzler Laurel J LJ Barbuch Robert R Bard Martin M Lawrence Christopher B CB Cramer Robert A RA
PLoS pathogens 20081107 11
At the site of microbial infections, the significant influx of immune effector cells and the necrosis of tissue by the invading pathogen generate hypoxic microenvironments in which both the pathogen and host cells must survive. Currently, whether hypoxia adaptation is an important virulence attribute of opportunistic pathogenic molds is unknown. Here we report the characterization of a sterol-regulatory element binding protein, SrbA, in the opportunistic pathogenic mold, Aspergillus fumigatus. L ...[more]
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