Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Wayne Yu
PROVIDER: E-GEOD-12531 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Zambidis Elias T ET Park Tea Soon TS Yu Wayne W Tam Ada A Levine Michal M Yuan Xuan X Pryzhkova Marina M Péault Bruno B
Blood 20080826 9
We report that angiotensin-converting enzyme (ACE), a critical physiologic regulator of blood pressure, angiogenesis, and inflammation, is a novel marker for identifying hemangioblasts differentiating from human embryonic stem cells (hESC). We demonstrate that ACE+CD45-CD34+/- hemangioblasts are common yolk sac (YS)-like progenitors for not only endothelium but also both primitive and definitive human lymphohematopoietic cells. Thrombopoietin and basic fibroblast growth factor are identified as ...[more]