Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Ross Hardison
PROVIDER: E-GEOD-35561 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Chou Stella T ST Byrska-Bishop Marta M Tober Joanna M JM Yao Yu Y Vandorn Daniel D Opalinska Joanna B JB Mills Jason A JA Choi John Kim JK Speck Nancy A NA Gadue Paul P Hardison Ross C RC Nemiroff Richard L RL French Deborah L DL Weiss Mitchell J MJ
Proceedings of the National Academy of Sciences of the United States of America 20121008 43
Patients with Down syndrome (trisomy 21, T21) have hematologic abnormalities throughout life. Newborns frequently exhibit abnormal blood counts and a clonal preleukemia. Human T21 fetal livers contain expanded erythro-megakaryocytic precursors with enhanced proliferative capacity. The impact of T21 on the earliest stages of embryonic hematopoiesis is unknown and nearly impossible to examine in human subjects. We modeled T21 yolk sac hematopoiesis using human induced pluripotent stem cells (iPSCs ...[more]