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Effect of cigarette smoke on normal human bronchial epithelial cells, and S9 toxicity

ABSTRACT: Temporal analysis of the effect of cigarette smoke on normal human bronchial epithelial cells (NHBE), and S9 toxicity.

ORGANISM(S): Homo sapiens

SUBMITTER: Mark Frank

PROVIDER: E-GEOD-1276 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Global gene expression analysis of human bronchial epithelial cells treated with tobacco condensates.

Jorgensen Ellen D ED Dozmorov Igor I Frank Mark B MB Centola Michael M Albino Anthony P AP

Cell cycle (Georgetown, Tex.) 20040910 9

Gene expression patterns were assessed in normal human bronchial epithelial (NHBE) cells exposed to cigarette smoke condensates (CSC) from commercial cigarettes in order to develop a better understanding of the genomic impact of tobacco exposure, and to define biomarkers that can potentially discriminate tobacco-related effects and outcomes in a clinical setting. NHBE cells were treated with CSCs from two American brands for up to 12 hours in the presence of S9 microsomal fraction from Aroclor 1 ...[more]

PMID: 15326394

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Effect of cigarette smoke on normal human bronchial epithelial cells, and S9 toxicity

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