Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

Transcription profiling of retina from Rp1-/- knockout vs littermate mice

ABSTRACT: Mice were a mixed background between 129/SvEv and C57BL/6. Rp1 knockout mice (Rp1-/-) and wildtype littermates examined. At P7, P10, P14, P18 and P21, mice were sacrificed and retinas removed. Each RNA sample included a pool of neural retinas from 3-4 mice. Retinas were all collected at 1-2 pm.

ORGANISM(S): Mus musculus

SUBMITTER: Jiewu Liu

PROVIDER: E-GEOD-128 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Distinct gene expression profiles and reduced JNK signaling in retinitis pigmentosa caused by RP1 mutations.

Liu Jiewu J Huang Qian Q Higdon Jason J Liu Wei W Xie Tao T Yamashita Tetsuji T Cheon Kyeogmi K Cheng Cheng C Zuo Jian J

Human molecular genetics 20050826 19

To understand the mechanisms underlying autosomal dominant progressive retinitis pigmentosa (RP) caused by the mutations of the RP1 gene and to identify molecules that play roles in the early disease process, we used Affymetrix U74Av2 microarrays to compare the gene expression profiles of retinas from Rp1-/- and Rp1+/+ mice at postnatal days (P) 7, 10, 14, 18 and 21. These profiles were independently verified by comparison with results of retinal serial analysis of gene expression, U74Av2 array ...[more]

PMID: 16126734

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Dataset Information

Transcription profiling of retina from Rp1-/- knockout vs littermate mice

Publications

Distinct gene expression profiles and reduced JNK signaling in retinitis pigmentosa caused by RP1 mutations.

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