CAMK1D amplification implicated in epithelial-mesenchymal transition in basal-like breast cancer
Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Jonathan Pollack
PROVIDER: E-GEOD-12827 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
CAMK1D amplification implicated in epithelial-mesenchymal transition in basal-like breast cancer.
Bergamaschi Anna A Kim Young H YH Kwei Kevin A KA La Choi Yoon Y Bocanegra Melanie M Langerød Anita A Han Wonshik W Noh Dong-Young DY Huntsman David G DG Jeffrey Stefanie S SS Børresen-Dale Anne-Lise AL Pollack Jonathan R JR
Molecular oncology 20081002 4
Breast cancer exhibits clinical and molecular heterogeneity, where expression profiling studies have identified five major molecular subtypes. The basal-like subtype, expressing basal epithelial markers and negative for estrogen receptor (ER), progesterone receptor (PR) and HER2, is associated with higher overall levels of DNA copy number alteration (CNA), specific CNAs (like gain on chromosome 10p), and poor prognosis. Discovering the molecular genetic basis of tumor subtypes may provide new op ...[more]
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