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Transcription profiling by array of human glioblastoma multiforme tumor cells exposed to cilengitide in a mouse xenograft model

ABSTRACT: Goal of this experiment is the identify differentially expressed genes in GBM zenografts that have been exposed to Cilengitide for 1 or 8 hours. A control with no cilengitide is also included. None of the tumors recieved radiation. Experiment Overall Design: 4 replicates of mice brains with tumor 103 are used as a control for expression with no cilengtide exposure. 4 replicates of mice brains with tumor 104 were exposed to cilengitide for 1 hour. 4 replicates of mice brains with tumor 105 were exposed to cilengitide for 8 hours.

ORGANISM(S): Homo sapiens

SUBMITTER: Brock Armstrong 

PROVIDER: E-GEOD-12949 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Radiation sensitization of glioblastoma by cilengitide has unanticipated schedule-dependency.

Mikkelsen Tom T   Brodie Chaya C   Finniss Susan S   Berens Michael E ME   Rennert Jessica L JL   Nelson Kevin K   Lemke Nancy N   Brown Stephen L SL   Hahn Diane D   Neuteboom Berend B   Goodman Simon L SL  

International journal of cancer 20090601 11

We investigated whether cilengitide could amplify the antitumor effects of radiotherapy in an orthotopic rat glioma xenograft model. Cilengitide is a specific inhibitor of alphav series integrins, and acts as an antiangiogenic. U251 human glioma cells express alphavbeta3 and alphavbeta5 integrins. We used in vitro assays of adhesion and growth of tumor and endothelial cells to evaluate cytotoxicity and the potential for cilengitide to enhance radiation toxicity. Treatment was then evaluated in a  ...[more]

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