Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

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Transcription profiling of SKGT4 and HET-1A cell lines exposed to deoxycholic acid (DCA)


ABSTRACT: This SuperSeries is composed of the following subset Series: GSE13376: Exposure of Barrett's associated adenocarcinoma cell lines SKGT4 to deoxycholic acid (DCA) GSE13378: Exposure of squamous esophageal cell line HET-1A to deoxycholic acid (DCA) Refer to individual Series

ORGANISM(S): Homo sapiens

SUBMITTER: Shane Duggan 

PROVIDER: E-GEOD-13400 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

An integrative genomic approach in oesophageal cells identifies TRB3 as a bile acid responsive gene, downregulated in Barrett's oesophagus, which regulates NF-kappaB activation and cytokine levels.

Duggan Shane P SP   Behan Fiona M FM   Kirca Murat M   Smith Sinead S   Reynolds John V JV   Long Aideen A   Kelleher Dermot D  

Carcinogenesis 20100205 5


Reflux of gastroduodenal contents and consequent inflammatory responses are associated with the development of Barrett's oesophagus (BO) and the promotion of oesophageal adenocarcinoma (OAC). Deregulation of inflammatory processes is a hallmark of oesophageal cancer. In this study, we aimed to investigate (i) the transcriptional responses to deoxycholic acid (DCA) in cell lines representative of either end of the oesophageal cancer sequence, (ii) the expression of DCA-regulated genes in data cha  ...[more]

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