Li-treatment-induced NDI (Li-NDI) in rats
Ontology highlight
ABSTRACT:
ORGANISM(S): Rattus norvegicus
SUBMITTER: Aleksandra Rojek
PROVIDER: E-GEOD-1341 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Altered expression of selected genes in kidney of rats with lithium-induced NDI.
Rojek Aleksandra A Nielsen Jakob J Brooks Heddwen L HL Gong Hong H Kim Young-Hee YH Kwon Tae-Hwan TH Frøkiaer Jørgen J Nielsen Søren S
American journal of physiology. Renal physiology 20050201 6
Lithium treatment is associated with development of nephrogenic diabetes insipidus, caused in part by downregulation of collecting duct aquaporin-2 (AQP2) and AQP3 expression. In the present study, we carried out cDNA microarray screening of gene expression in the inner medulla (IM) of lithium-treated and control rats, and selected genes were then investigated at the protein level by immunoblotting and/or immunohistochemistry. The following genes exhibited significantly altered transcription and ...[more]
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