Transcriptional analysis of RelE family toxin overexpression in Mycobacterium tuberculosis
Ontology highlight
ABSTRACT:
ORGANISM(S): Mycobacterium tuberculosis
SUBMITTER: Helena Boshoff
PROVIDER: E-GEOD-13998 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
The three RelE homologs of Mycobacterium tuberculosis have individual, drug-specific effects on bacterial antibiotic tolerance.
Singh Ramandeep R Barry Clifton E CE Boshoff Helena I M HI
Journal of bacteriology 20100108 5
In Escherichia coli, expression of the RelE and HipA toxins in the absence of their cognate antitoxins has been associated with generating multidrug-tolerant "persisters." Here we show that unlike persisters of E. coli, persisters of Mycobacterium tuberculosis selected with one drug do not acquire cross-resistance to other classes of drugs. M. tuberculosis has three homologs of RelE arranged in operons with their apparent antitoxins. Each toxin individually arrests growth of both M. tuberculosis ...[more]
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