Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

Gene expression analysis & Comparative genomic hybridization from Lung cancer Cell lines

ABSTRACT: Gene expression and Comparative genomic hybridization (CGH) microarrays performed in a set of 8 Lung cancer Cell lines. The search for oncogenes is becoming increasingly important in cancer genetics because they constitute suitable targets for therapeutic intervention. To identify novel oncogenes, activated by gene amplification, we performed high-resolution CGH (Comparative Genome Hybridization) analysis on cDNA microarrays and compared DNA copy number and mRNA expression levels in lung cancer cell lines. We have performed both microarrays (expression and CGH) in a set of 8 human lung cancer cell lines: Calu3, H23, H441, A427, H522, A549, H1299, H2126.

ORGANISM(S): Homo sapiens

SUBMITTER: Pedro Medina-Vico

PROVIDER: E-GEOD-14079 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

The SRY-HMG box gene, SOX4, is a target of gene amplification at chromosome 6p in lung cancer.

Medina Pedro P PP Castillo Sandra D SD Blanco Sandra S Sanz-Garcia Marta M Largo Cristina C Alvarez Sara S Yokota Jun J Gonzalez-Neira Ana A Benitez Javier J Clevers Hans C HC Cigudosa Juan C JC Lazo Pedro A PA Sanchez-Cespedes Montse M

Human molecular genetics 20090119 7

The search for oncogenes is becoming increasingly important in cancer genetics because they are suitable targets for therapeutic intervention. To identify novel oncogenes, activated by gene amplification, we analyzed cDNA microarrays by high-resolution comparative genome hybridization and compared DNA copy number and mRNA expression levels in lung cancer cell lines. We identified several amplicons (5p13, 6p22-21, 11q13, 17q21 and 19q13) that had a concomitant increase in gene expression. These r ...[more]

PMID: 19153074

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Dataset Information

Gene expression analysis & Comparative genomic hybridization from Lung cancer Cell lines

Publications

The SRY-HMG box gene, SOX4, is a target of gene amplification at chromosome 6p in lung cancer.

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