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Malignant Fibrous Histiocytoma - Pleomorphic Sarcoma, NOS -Gene expression, Histology and clinical course -A pilot study

ABSTRACT: This study was performed to identify gene expression differences in not otherwise specified soft tissue sarcomas (NOS, malignant fibrous histiocytomas) and correlate them to histological findings and the clinical course. RNA was isolated and differential gene expression was analysed by the microarray technique. We used microarrays to detail the global gene expression differences between primary soft tissue sarcoma samples, harvested intraoperatively. Keywords: response to chemotherapeutic agent We compared the gene expression of ten different tumor samples of MFH/NOS sarcoma to determine global gene expression differences by microarray analysis.

ORGANISM(S): Homo sapiens

SUBMITTER: Ludger Klein-Hitpass

PROVIDER: E-GEOD-14325 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Malignant fibrous histiocytoma--pleomorphic sarcoma, NOS gene expression, histology, and clinical course. A pilot study.

Daigeler Adrien A Klein-Hitpass Ludger L Stricker Ingo I Müller Oliver O Kuhnen Cornelius C Chromik Ansgar Michael AM Steinstraesser Lars L Goertz Ole O Steinau Hans-Ulrich HU Lehnhardt Marcus M

Langenbeck's archives of surgery 20090122 3

<h4>Purpose</h4>The new classification of malignant fibrous histiocytoma leaves only a small group of tumors without further line of differentiation, so-called pleomorphic sarcomas, not otherwise specified (NOS) as a pseudo-entity. This study focused on these tumors and analyzed the association of gene expression profiles to clinical outcome.<h4>Materials and methods</h4>Ten fresh samples of pleomorphic NOS sarcomas were evaluated histopathologically and by means of microarray analysis. Analysis ...[more]

PMID: 19159951

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Malignant Fibrous Histiocytoma - Pleomorphic Sarcoma, NOS -Gene expression, Histology and clinical course -A pilot study

Project description:This study was performed to identify gene expression differences in not otherwise specified soft tissue sarcomas (NOS, malignant fibrous histiocytomas) and correlate them to histological findings and the clinical course. RNA was isolated and differential gene expression was analysed by the microarray technique. We used microarrays to detail the global gene expression differences between primary soft tissue sarcoma samples, harvested intraoperatively. Keywords: response to chemotherapeutic agent

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Trancription profiling of human soft tissue sarcomas: characterization & reclassification of malignant fibrous histiocytoma

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