Unknown,Transcriptomics,Genomics,Proteomics

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Transcription profiling of extraocular, hindlimb and cardiac muscles from dKO and MDX mice

ABSTRACT: Comparison by expression profiling of tissue from dKO (utrophin/dystrophin-deficient) and MDX mice at 8 weeks of age. Independent triplicate analyses/strain were done for extraocular, hindlimb, and cardiac muscle.

ORGANISM(S): Mus musculus

SUBMITTER: Henry Kaminski 

PROVIDER: E-GEOD-1463 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Analysis of gene expression differences between utrophin/dystrophin-deficient vs mdx skeletal muscles reveals a specific upregulation of slow muscle genes in limb muscles.

Baker Patrick E PE   Kearney Jessica A JA   Gong Bendi B   Merriam Anita P AP   Kuhn Donald E DE   Porter John D JD   Rafael-Fortney Jill A JA  

Neurogenetics 20060309 2

Dystrophin deficiency leads to the progressive muscle wasting disease Duchenne muscular dystrophy (DMD). Dystrophin-deficient mdx mice are characterized by skeletal muscle weakness and degeneration but they appear outwardly normal in contrast to DMD patients. Mice lacking both dystrophin and the dystrophin homolog utrophin [double knockout (dko)] have muscle degeneration similar to mdx mice, but they display clinical features similar to DMD patients. Dko limb muscles also lack postsynaptic membr  ...[more]

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