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Transcription profiling of human IBS patients before and after treatment

ABSTRACT: Increased numbers of mast cells and their products have been linked to symptom onset and severity in patients with chronic diarrhea and abdominal pain. Although mast-cell inhibition ameliorates clinical manifestations and reduces mucosal inflammation, underlying molecular mechanisms remain unknown. Experiment Overall Design: Diarrhea-irritable bowel syndrome (d-IBS) patients were studied at baseline, or 6 months after natural evolution (control) or oral cromoglycate treatment. Jejunal biopsies were subjected to chip analysis (Affymetrix Human Genome U133 Plus 2.0 GeneChips).

ORGANISM(S): Homo sapiens

SUBMITTER: Cristina Martinez

PROVIDER: E-GEOD-14842 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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