Dataset Information

Colonic proteome signature in immunoproteasome-deficient stressed mice and its relevance for irritable bowel syndrome

ABSTRACT: A role for immunoproteasome in the regulation of intestinal permeability has been previously suggested both in mice during water avoidance stress (WAS) and in patients with irritable bowel syndrome (IBS). We thus aimed (i) to evaluate the colonic proteome in wild-type (wt) and β2i immunoproteasome subunit knock-out (β2i-/-) mice during WAS and (ii) to investigate the colonic expression of 49 ubiquitinated-proteins in diarrhea-predominant IBS patients (IBS-D).

INSTRUMENT(S): 6550 iFunnel Q-TOF LC/MS

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Epithelial Cell, Colon

DISEASE(S): Irritable Bowel Syndrome

SUBMITTER: Alexis Goichon

LAB HEAD: Goichon A

PROVIDER: PXD011199 | Pride | 2018-12-05

REPOSITORIES: Pride

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	1e5f3472a54ff335___AG-151105_Spot1.mgf.export.F074946.mzid.gz	Mzid
	1e5f3472a54ff335___AG-151105_Spot1.mgf.export.F074946.pride.mztab.gz	Mztab
	1e5f3472a54ff335___AG-151105_Spot10.mgf.export.F074957.mzid.gz	Mzid
	1e5f3472a54ff335___AG-151105_Spot10.mgf.export.F074957.pride.mztab.gz	Mztab
	1e5f3472a54ff335___AG-151105_Spot10bis.mgf.export.F074958.mzid.gz	Mzid

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Publications

Colonic Proteome Signature in Immunoproteasome-Deficient Stressed Mice and Its Relevance for Irritable Bowel Syndrome.

Goichon Alexis A Bahlouli Wafa W Ghouzali Ibtissem I Chan Philippe P Vaudry David D Déchelotte Pierre P Ducrotté Philippe P Coëffier Moïse M

Journal of proteome research 20181126 1

A role for immunoproteasome in the regulation of intestinal permeability has been previously suggested both in mice during water avoidance stress (WAS) and in patients with irritable bowel syndrome (IBS). Here, we provide evidence that the ubiquitin-proteasome system (UPS) contributes to the pathophysiology of IBS. Indeed, we report that colonic proteome is altered in WAS mice and that β2i subunit deficiency modifies the proteome response that is associated with a limitation of colonic hyperperm ...[more]

PMID: 30475625

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