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Transcription profiling of mouse LPS-stimulated macrophages from wild-type and Zc3h12a-/- knockouts

ABSTRACT: Lipopolysaccharide (LPS), a Toll-like receptor (TLR) 4 ligand, induces the expression of various genes including proinflammatory cytokines, and the expression is modified by the presence of Zc3h12a. We used microarrays to examine influence of Zc3h12a deficiency in LPS-inducible gene expression. Experiment Overall Design: Peritoneal macrophages from wild-type and Zc3h12a-/- mice were stimulated with LPS for 0, 1, 2 and 4 hours, followed by RNA extraction. Then hybridization on affymetrix microarrays was performed.

ORGANISM(S): Mus musculus

SUBMITTER: Osamu Takeuchi

PROVIDER: E-GEOD-14891 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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