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Global expression profiling of CD4 T-cell responses to house dust mite allergens in human atopics and nonatopics.

ABSTRACT: The aim of this study was to employ a systems-level analysis to elucidate gene expression networks operating in the CD4 T-cell responses which underpin human atopic disease. Keywords: Disease state analysis; T-cell response The study design consisted of 45 subjects, including 30 HDM-sensitized atopics, and 15 nonatopic controls. For each subject, gene expression was profiled in paired samples of HDM-stimulated CD4 T-cells and in unstimulated CD4 T-cells (baseline control), thus the microarray data set consists of 90 microarrays.

ORGANISM(S): Homo sapiens

SUBMITTER: Patrick Holt

PROVIDER: E-GEOD-14908 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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A network modeling approach to analysis of the Th2 memory responses underlying human atopic disease.

Bosco Anthony A McKenna Kathy L KL Firth Martin J MJ Sly Peter D PD Holt Patrick G PG

Journal of immunology (Baltimore, Md. : 1950) 20090501 10

Complex cellular functions within immunoinflammatory cascades are conducted by networks of interacting genes. In this study, we employed a network modeling approach to dissect and interpret global gene expression patterns in allergen-induced Th cell responses that underpin human atopic disease. We demonstrate that a subnet of interconnected genes enriched for Th2 and regulatory T cell-associated signatures plus many novel genes is hardwired into the atopic response and is a hallmark of atopy at ...[more]

PMID: 19414752

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