Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Cheng Li
PROVIDER: E-GEOD-15225 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Li Cheng C Kim Sang-Woo SW Rai Deepak D Bolla Aswani R AR Adhvaryu Siddharth S Kinney Marsha C MC Robetorye Ryan S RS Aguiar Ricardo C T RC
Blood 20090310 26
MicroRNA (miRNA) deregulation contributes to cancer pathogenesis. However, analysis of miRNAs in diffuse large B-cell lymphoma (DLBCL) has been hindered by a focus on cell lines, limited number of miRNAs examined, and lack of copy number data. To address these restrictions, we investigated genomewide miRNA expression and copy number data in 86 DLBCLs. Permutation analysis showed that 63 miRNAs were recurrently disrupted in DLBCL, including highly expressed oncomirs not previously linked to chrom ...[more]