Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Phillip Dumesic
PROVIDER: E-GEOD-15417 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
The Journal of cell biology 20090501 3
Erk1/2 mitogen-activated protein kinases (MAPKs) are often hyperactivated in human cancers, where they affect multiple processes, including proliferation. However, the effects of Erk1/2 loss in normal epithelial tissue, the setting of most extracellular signal-regulated kinase (Erk)-associated neoplasms, are unknown. In epidermis, loss of Erk1 or Erk2 individually has no effect, whereas simultaneous Erk1/2 depletion inhibits cell division, demonstrating that these MAPKs are necessary for normal ...[more]