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Top1

ABSTRACT: Thebaine and oripavine accumulating mutant (Norman) verses wildtype. Keywords = Opium Poppy, Secondary Metabolism

ORGANISM(S): Papaver somniferum

SUBMITTER: Anthony Millgate

PROVIDER: E-GEOD-1543 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Analgesia: morphine-pathway block in top1 poppies.

Millgate Anthony G AG Pogson Barry J BJ Wilson Iain W IW Kutchan Toni M TM Zenk Meinhart H MH Gerlach Wayne L WL Fist Anthony J AJ Larkin Philip J PJ

Nature 20040901 7007

The opium poppy is a source of the pharmaceuticals codeine, morphine and their derived analgesics. Here we describe the initial characterization of the poppy mutant known as top1 (for 'thebaine oripavine poppy 1'), which accumulates the morphine and codeine precursors thebaine and oripavine and does not complete their biosynthesis into morphine and codeine. The original discovery of top1 stimulated a re-engineering of the opioid industry in the island state of Tasmania, which grows over 40% of t ...[more]

PMID: 15386001

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