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Expression data from lung of mice bearing mutations of FGFR3 and FGFR4

ABSTRACT: Gene expression profiling of newborn lung tissue revealed few changes in compound FGFR3/FGFR4 deficient mice, consistent with their normal lung morphology at birth, suggesting the sequence of events leading to the phenotype initiates after birth in this model. Profiling of 4 week-old lung tissues revealed an induction of genes related to elastic fiber assembly in compound mutants. Lung RNA isolated from three animals of each genotype-age group were pooled for each Affymetrix chip (n=3 chips for each, except n=2 for wild type at 4 weeks.

ORGANISM(S): Mus musculus

SUBMITTER: Sorachai Srisuma

PROVIDER: E-GEOD-15452 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Fibroblast growth factor receptors control epithelial-mesenchymal interactions necessary for alveolar elastogenesis.

Srisuma Sorachai S Bhattacharya Soumyaroop S Simon Dawn M DM Solleti Siva K SK Tyagi Shivraj S Starcher Barry B Mariani Thomas J TJ

American journal of respiratory and critical care medicine 20100121 8

<h4>Rationale</h4>The mechanisms contributing to alveolar formation are poorly understood. A better understanding of these processes will improve efforts to ameliorate lung disease of the newborn and promote alveolar repair in the adult. Previous studies have identified impaired alveogenesis in mice bearing compound mutations of fibroblast growth factor (FGF) receptors (FGFRs) 3 and 4, indicating that these receptors cooperatively promote postnatal alveolar formation.<h4>Objectives</h4>To determ ...[more]

PMID: 20093646

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