Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Helen Hurst
PROVIDER: E-GEOD-15481 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Williams Christopher M J CM Scibetta Angelo G AG Friedrich J Karsten JK Canosa Monica M Berlato Chiara C Moss Charlotte H CH Hurst Helen C HC
The EMBO journal 20091001 22
Overexpression of the activator protein (AP)-2gamma transcription factor in breast tumours has been identified as an independent predictor of poor outcome and failure of hormone therapy. To understand further the function of AP-2gamma in breast carcinoma, we have used an RNA interference and gene expression profiling strategy with the MCF-7 cell line as a model. Gene expression changes between control and silenced cells implicate AP-2gamma in the control of cell cycle progression and development ...[more]