Unknown,Transcriptomics,Genomics,Proteomics

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The effect of PPARa siRNA on endothelial cells treated with fenofibrate


ABSTRACT: Fenofibrate is a synthetic ligand for the nuclear receptor peroxisome proliferator-activated receptor (PPAR) alpha, but there are reports that fenofibrate affects endothelial cells in PPARa-independent manner. In order to identify PPARa-dependently and PPARa-independently regulated transcripts we generated microarray data from human endothelial cells treated with fenofibrate with and without siRNA-mediated knock-down of PPARa. In this study, we generated microarray data from human umbilical vein endothelial cells (HUVECs) treated with fenofibrate with pretreatment PPARa or control siRNA. There are four time points (4, 8, 12 and 18hours) (n=1 at each time point).

ORGANISM(S): Homo sapiens

SUBMITTER: Atsushi Doi 

PROVIDER: E-GEOD-15482 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Analysis of PPARalpha-dependent and PPARalpha-independent transcript regulation following fenofibrate treatment of human endothelial cells.

Araki Hiromitsu H   Tamada Yoshinori Y   Imoto Seiya S   Dunmore Ben B   Sanders Deborah D   Humphrey Sally S   Nagasaki Masao M   Doi Atsushi A   Nakanishi Yukiko Y   Yasuda Kaori K   Tomiyasu Yuki Y   Tashiro Kousuke K   Print Cristin C   Charnock-Jones D Stephen DS   Kuhara Satoru S   Miyano Satoru S  

Angiogenesis 20090409 3


Fenofibrate is a synthetic ligand for the nuclear receptor peroxisome proliferator-activated receptor (PPAR) alpha and has been widely used in the treatment of metabolic disorders, especially hyperlipemia, due to its lipid-lowering effect. The molecular mechanism of lipid-lowering is relatively well defined: an activated PPARalpha forms a PPAR-RXR heterodimer and this regulates the transcription of genes involved in energy metabolism by binding to PPAR response elements in their promoter regions  ...[more]

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