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The effect of fenofibrate on endothelial cells

ABSTRACT: Fenofibrate is a synthetic ligand for the nuclear receptor peroxisome proliferator-activated receptor (PPAR) alpha, but there are reports that fenofibrate affects endothelial cells in PPARa-independent manner. In order to identify PPARa-dependently and PPARa-independently regulated transcripts we generated microarray data from human endothelial cells treated with fenofibrate with and without siRNA-mediated knock-down of PPARa. In this study, we generated microarray data from human umbilical vein endothelial cells (HUVECs) treated with fenofibrate. Time 0 indicates the start point of observation immediately prior to exposure to the 25umol fenofibrate. There are five time points (2, 4, 6, 8, and 18hours) (n=3 at each time point). The control is untreatment HUVEC (n=4).

ORGANISM(S): Homo sapiens

SUBMITTER: Atsushi Doi 

PROVIDER: E-GEOD-15483 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Analysis of PPARalpha-dependent and PPARalpha-independent transcript regulation following fenofibrate treatment of human endothelial cells.

Araki Hiromitsu H   Tamada Yoshinori Y   Imoto Seiya S   Dunmore Ben B   Sanders Deborah D   Humphrey Sally S   Nagasaki Masao M   Doi Atsushi A   Nakanishi Yukiko Y   Yasuda Kaori K   Tomiyasu Yuki Y   Tashiro Kousuke K   Print Cristin C   Charnock-Jones D Stephen DS   Kuhara Satoru S   Miyano Satoru S  

Angiogenesis 20090409 3

Fenofibrate is a synthetic ligand for the nuclear receptor peroxisome proliferator-activated receptor (PPAR) alpha and has been widely used in the treatment of metabolic disorders, especially hyperlipemia, due to its lipid-lowering effect. The molecular mechanism of lipid-lowering is relatively well defined: an activated PPARalpha forms a PPAR-RXR heterodimer and this regulates the transcription of genes involved in energy metabolism by binding to PPAR response elements in their promoter regions  ...[more]

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