Intestinal cells infected with Vibrio cholerae
Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Neil Stokes
PROVIDER: E-GEOD-1549 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Transcriptional responses of intestinal epithelial cells to infection with Vibrio cholerae.
Stokes Neil R NR Zhou Xin X Meltzer Stephen J SJ Kaper James B JB
Infection and immunity 20040701 7
Vibrio cholerae is a noninvasive enteric bacterium that causes the severe diarrheal disease cholera. Candidate cholera vaccines have been engineered by deleting genes encoding known virulence factors in V. cholerae; however, many of these attenuated strains were still reactogenic in human volunteers. In this study, DNA arrays were utilized to monitor the transcriptional responses of human intestinal epithelial cells (T84) to eight strains of V. cholerae, including attenuated, toxigenic, and envi ...[more]
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