Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

0

Transcription profiling of rats with terminal heart failure and cachexia


ABSTRACT: Rats overexpressing the human renin and angiotensinogen genes die after seven weeks of end organ damage. They develop hypertension, heart hypertrophy and proteinuria.We compared terminal heart failure, these are indeed terminally ill to double transgenic animals suffering on hypertension, proteinuria and heart hypertrophy. In addition, Losartan-treated animals (10 mg/kg/d)showed similar physiological parameters (normotension, no proteinuria and no heart hypertrophy compared to control sprague dawley rats.

ORGANISM(S): Rattus norvegicus

SUBMITTER: Maren Wellner 

PROVIDER: E-GEOD-1557 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

altmetric image

Publications


About one-half of double transgenic rats (dTGR) overexpressing the human renin and angiotensinogen genes die by age 7 wk of terminal heart failure (THF); the other (preterminal) one-half develop cardiac damage but survive. Our study's aim was to elucidate cardiac gene expression differences in dTGR-THF compared with dTGR showing compensated cardiac hypertrophy but not yet THF. dTGR treated with losartan (LOS) and nontransgenic rats (SD) served as controls. THF-dTGR body weight was significantly  ...[more]

Similar Datasets

2005-01-03 | GSE1557 | GEO
2023-01-27 | GSE140948 | GEO
2006-08-31 | E-MEXP-357 | biostudies-arrayexpress
2014-03-31 | E-GEOD-51593 | biostudies-arrayexpress
2012-11-05 | E-GEOD-34552 | biostudies-arrayexpress
2021-09-08 | GSE183339 | GEO
2012-11-05 | GSE34552 | GEO
2014-03-31 | GSE51593 | GEO
2010-09-23 | E-GEOD-18298 | biostudies-arrayexpress
2023-05-24 | E-MTAB-12671 | biostudies-arrayexpress