Ontology highlight
ABSTRACT:
ORGANISM(S): Rattus norvegicus
SUBMITTER: Maren Wellner
PROVIDER: E-GEOD-1557 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Wellner Maren M Dechend Ralf R Park Joon-Keun JK Shagdarsuren Erdenechimeg E Al-Saadi Nidal N Kirsch Torsten T Gratze Petra P Schneider Wolfgang W Meiners Silke S Fiebeler Anette A Haller Hermann H Luft Friedrich C FC Muller Dominik N DN
Physiological genomics 20041228 3
About one-half of double transgenic rats (dTGR) overexpressing the human renin and angiotensinogen genes die by age 7 wk of terminal heart failure (THF); the other (preterminal) one-half develop cardiac damage but survive. Our study's aim was to elucidate cardiac gene expression differences in dTGR-THF compared with dTGR showing compensated cardiac hypertrophy but not yet THF. dTGR treated with losartan (LOS) and nontransgenic rats (SD) served as controls. THF-dTGR body weight was significantly ...[more]