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Over expression of mRNA for multiple genes including insulin in the PLN of NOD is associated with Islet Autoimmunity


ABSTRACT: The aim of this study is to identify genes implicated in the early steps of the autoimmune process, prior to inflammation in type 1 diabetes. Early Insulin AutoAntibodies (E-IAA) have been used as subphenotypic marker to select individual animals as type 1 diabetes prone and to compare gene expression patterns with insulin autoantibody negative NOD. Variation of gene expression patterns in the pancreatic lymph nodes (PLN) issued from E-IAA positive and negative mice have been analyzed by DNA microarrays PLN were used from 5 weeks old NOD mice positive for Insulin Autoantibodies and compared with animals negative for Insulin AutoAntibodies

ORGANISM(S): Mus musculus

SUBMITTER: Evie Melanitou 

PROVIDER: E-GEOD-15582 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Early over expression of messenger RNA for multiple genes, including insulin, in the Pancreatic Lymph Nodes of NOD mice is associated with Islet Autoimmunity.

Regnault Béatrice B   Osorio Y Fortea José J   Miao Dongmei D   Eisenbarth George G   Melanitou Evie E  

BMC medical genomics 20091002


<h4>Background</h4>Autoimmune diabetes (T1D) onset is preceded by a long inflammatory process directed against the insulin-secreting beta cells of the pancreas. Deciphering the early autoimmune mechanisms represents a challenge due to the absence of clinical signs at early disease stages. The aim of this study was to identify genes implicated in the early steps of the autoimmune process, prior to inflammation, in T1D. We have previously established that insulin autoantibodies (E-IAA) predict ear  ...[more]

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